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Overdijk MB, Jansen JHM, Nederend M, Lammerts van Bueren JJ, Groen RWJ, Parren PWHI

Reduces Fat Cell Size and Promotes Lipolysis Research indicates that NNMT inhibition leads to shrinkage of white adipose tissue and a shift toward fat oxidation , making the body more efficient at burning stored fat for energy

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In an environment with elevated CD38 activity, such as seen in SSc lesional skin, administering NAD + precursors or enhancing NAD + synthesis will have limited effect on increasing NAD + levels, as elevated CD38 continues to degrade NAD +